Protein Details: Gap junction alpha-1 protein

Protein ID

ICDB_Pro_0229

Protein Name

Gap junction alpha-1 protein

Gene Name

gja1; cx43; shf; sof

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Length

381 amino acids

AlphaFoldDB

AF-O57474-F1-model_v4.pdb

Function

Sequence

MGDWSALGRLLDKVQAYSTAGGKVWLSVLFIFRILVLGTAVESAWGDEQSAFKCNTQQPGCENVCYDKSFPISHVRFWVLQIIFVSTPTLLYLAHVFYLMRKEEKLNRKEEELKAVQNDGGDVELHLKKIELKKFKHGLEEHGKVKMKGSLLRTYIFSIIFKSICEVVFLVIQWYLYGFSLSAVYTCERTPCPHRVDCFLSRPTEKTIFIIFMLVVSLFSLLLNIIELFYVLFKRIKDRVKSRQNTQFPTGTLSPTPKELSTTKYAYYNGCSSPTAPLSPMSPPGYKLATGERTNSCRNYNKQANEQNWANYSTEQNRLGQNGSTISNSHAQAFDYPDDTHEHKKLTPGHELQPLALIDARPCSRASSRMSSRARPDDLDV

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Expressed in adult ovary; heart; lens and liver. In growing caudal fins; expressed in cells flanking the germinal region of newly growing segments and in osteoblasts at segment boundaries.

DOI ID

10.1016/j.ydbio.2004.11.005; 10.1002/dvdy.20426; 10.1038/nature12111; 10.1002/dvdy.10436

RefSeq

NP_571113.1 [O57474-1]